The microbial metabolite desaminotyrosine protects from influenza through type I interferon
نویسندگان
چکیده
منابع مشابه
Type I interferon signaling protects mice from lethal henipavirus infection.
Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are resistant to henipavirus infection. We report ...
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OBJECTIVE Low-grade chronic inflammation emerges as a potent driver of insulin resistance and glucose dysregulation in obesity and associated non-alcoholic fatty liver disease (NAFLD). The liver, subcutaneous fat and the immune system participate in disturbances of metabolism. Type I interferon (IFN) signalling initiated by innate and adaptive immunity modulates inflammatory responses consequen...
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Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1). Sod1(-/-) mice exhibited increased inflammation and aggravated liver damage upon viral infection, which was i...
متن کاملEnteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.
BACKGROUND Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfection with respiratory viruses is not clear. OBJECTIVE Here we investigated the effects of strictly enteric helminth infection with Heligmosomoi...
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* Author for correspondence: Head of Discipline, Discipline of Microbiology and Immunology, M502 School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia. Tel: (08) 9346 2217, Fax: (08) 9346 2912, Email: [email protected]. Abstract. The persistence of highly pathogenic avian influenza virus within wild bird ...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aam5336